CMOS integrated DNA microarray based on GMR sensors

Han S.-J., Xu L., Yu H., Wilson R.J., White R.L., Pourmand N., Wang S.X.
Dept. of Materials Sci. and Eng., Stanford University, Stanford, CA 94305, United States; Dept. of Electrical Engineering, Stanford University; Stanford Genome Technology Center, Palo Alto, CA 94304, United States

Abstract: A high density GMR sensor array was integrated with a standard CMOS chip for DNA hybridization detection. Absorption of magnetic nanoparticles by the hybridized DNA alters the sensor resistance, and generated electrical signals are directly measured with the on-die circuitry. The proposed biochip can be applied to other bio-reaction detection, e.g. protein assay, through different surface modifications.

Year: 2006
Source title: Technical Digest - International Electron Devices Meeting, IEDM
Art. No.: 4154306
Link: Scorpus Link
Document Type: Conference Paper
Source: Scopus
Authors with affiliations:

1. Han, S.-J., Dept. of Materials Sci. and Eng., Stanford University, Stanford, CA 94305, United States
2. Xu, L., Dept. of Materials Sci. and Eng., Stanford University, Stanford, CA 94305, United States
3. Yu, H., Stanford Genome Technology Center, Palo Alto, CA 94304, United States
4. Wilson, R.J., Dept. of Materials Sci. and Eng., Stanford University, Stanford, CA 94305, United States
5. White, R.L., Dept. of Materials Sci. and Eng., Stanford University, Stanford, CA 94305, United States, Dept. of Electrical Engineering, Stanford University
6. Pourmand, N., Stanford Genome Technology Center, Palo Alto, CA 94304, United States
7. Wang, S.X., Dept. of Materials Sci. and Eng., Stanford University, Stanford, CA 94305, United States, Dept. of Electrical Engineering, Stanford University

Download Abstract: biochips60.pdf