Progress in using magnetic nanoobjects for biomedical diagnostics

Kataeva N., Schotter J., Shoshi A., Heer R., Eggeling M., Bethge O., Nohammer C., Bruckl H.
Austrian Research Centers, Division 'Nano-System-Technologies', Donau-City-Str. 1, 1220 Vienna, Austria; Austrian Research Centers, Division 'Life Sciences', 2444 Seibersdorf, Austria

Abstract: A magnetic biochip using the combination of both magnetic nanoobjects as markers and magnetoresistive sensors has proven to be competitive to standard fluorescent DNA-detection at low concentrations. Magnetic nanoobjects additionally provide the unique possibility to actively manipulate biomolecules, on-chip, which paves the way to an integrated 'magnetic lab-on-a-chip' containing detection and manipulation. It is shown that the hybridization process can be accelerated on a biochip. Looking forward, a paradigm change from the 'magnetic lab-on-a-chip' to a 'magnetic lab-on-a-bead' is discussed as a future device solution. The ferromagnetic nanoobjects themselves are thereby directly used both as molecular recognition site and as detection unit. © 2008 American Institute of Physics.
Author Keywords: Biochip; Diagnostics; GMR; Magnetic nanoparticle; Magnetoresistance; Plasmon

Year: 2008
Source title: AIP Conference Proceedings
Volume: 1025
Page : 28-33
Link: Scorpus Link
Document Type: Conference Paper
Source: Scopus
 Authors with affiliations:
  1. Kataeva, N., Austrian Research Centers, Division 'Nano-System-Technologies', Donau-City-Str. 1, 1220 Vienna, Austria
  2. Schotter, J., Austrian Research Centers, Division 'Nano-System-Technologies', Donau-City-Str. 1, 1220 Vienna, Austria
  3. Shoshi, A., Austrian Research Centers, Division 'Nano-System-Technologies', Donau-City-Str. 1, 1220 Vienna, Austria
  4. Heer, R., Austrian Research Centers, Division 'Nano-System-Technologies', Donau-City-Str. 1, 1220 Vienna, Austria
  5. Eggeling, M., Austrian Research Centers, Division 'Nano-System-Technologies', Donau-City-Str. 1, 1220 Vienna, Austria
  6. Bethge, O., Austrian Research Centers, Division 'Nano-System-Technologies', Donau-City-Str. 1, 1220 Vienna, Austria
  7. Nöhammer, C., Austrian Research Centers, Division 'Life Sciences', 2444 Seibersdorf, Austria
  8. Brückl, H., Austrian Research Centers, Division 'Nano-System-Technologies', Donau-City-Str. 1, 1220 Vienna, Austria
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