Ferromagnetic resonance biochip for diagnosing pancreatic cancer

Casler E., Chae S., Kunduru V., Bothara M., Yang E., Ghinoea S., Dhagat P., Prasad S.
Portland State University, Biomedical Microdevices and Nanotechnology Lab, Portland, OR, United States; Oregon State University, Applied Magnetics Laboratory

Abstract: The objective of the paper is to develop a "lab-on-a-chip" device for early disease (pancreatic cancer) diagnosis by using ferromagnetic resonance (FMR). Magnetic microbeads, which are functionalized for target molecules (antigens), are immobilized by antigen-antibody reactions on the surface of a microwave circuit. These magnetic labels are detected inductively using FMR, which detects a single bead with a sensitivity of 1-10 μV/V. This method has distinctive advantages compared to other conventional immunoassay techniques; it requires a small sample volume, is non-invasive, cost effective, and easy to implement. It also does not alter the native properties of the antigen and antibody complex.
Author Keywords: Biomarker; Cancer; Immunoassay; Microbead

Year: 2008
Source title: Technical Proceedings of the 2008 NSTI Nanotechnology Conference and Trade Show, NSTI-Nanotech, Nanotechnology 2008
Volume: 3
Page : 347-350
Link: Scorpus Link
Document Type: Conference Paper
Source: Scopus
 Authors with affiliations:
  1. Casler, E., Portland State University, Biomedical Microdevices and Nanotechnology Lab, Portland, OR, United States
  2. Chae, S., Portland State University, Biomedical Microdevices and Nanotechnology Lab, Portland, OR, United States
  3. Kunduru, V., Portland State University, Biomedical Microdevices and Nanotechnology Lab, Portland, OR, United States
  4. Bothara, M., Portland State University, Biomedical Microdevices and Nanotechnology Lab, Portland, OR, United States
  5. Yang, E., Portland State University, Biomedical Microdevices and Nanotechnology Lab, Portland, OR, United States
  6. Ghinoea, S., Oregon State University, Applied Magnetics Laboratory
  7. Dhagat, P., Oregon State University, Applied Magnetics Laboratory
  8. Prasad, S., Portland State University, Biomedical Microdevices and Nanotechnology Lab, Portland, OR, United States
Download Abstract: biochips31.pdf