Measuring and extraction of biological information on new handheld biochip-based microsystem

Lopes P.A.C., Germano J., De Almeida T.M., Sousa L.A., Piedade M.S., Cardoso F.A., Ferreira H.A., Freitas P.P.
Instituto Superior Técnico, Technical University of Lisbon, 1049-001 Lisbon, Portugal; Instituto de Engenharia de Sistemas e Computadores- Investigação e Desenvolvimento, 1000-02 Lisbon, Portugal; Instituto de Engenharia de Sistemas e Computadores Microsistemas and Nanotecnologias (INESC-MN), 1000-029 Lisbon, Portugal

Abstract: This paper proposes techniques for the extraction of biological information in a recently developed handheld biochip-based microsystem. The microsystem is based on a magnetoresistive array biochip composed of a number of sensing sites with magnetic tunneling junctions (MTJ) and diodes. Different techniques are addressed to drive the MTJs with different types of signals. Different filtering strategies that allow the recovery of biological signals from the noise without overly increasing either the time required for accessing the sensors or the power consumption of the board are proposed. Finally, new techniques and algorithms are proposed to deal with the variability of the fabrication parameters of the MTJ and the diodes. Experiments with the system in a setup to detect actual biological signals are presented with encouraging results. © 2008 IEEE.
Author Keywords: Biochip; Biomolecules; Magnetic sensors; Microsystem; Signal processing

Year: 2010
Source title: IEEE Transactions on Instrumentation and Measurement
Volume: 59
Issue: 1
Art. No.: 4652562
Page : 56-62
Link: Scorpus Link
Document Type: Conference Paper
Source: Scopus
 Authors with affiliations:
  1. Lopes, P.A.C., Instituto Superior Técnico, Technical University of Lisbon, 1049-001 Lisbon, Portugal
  2. Germano, J., Instituto Superior Técnico, Technical University of Lisbon, 1049-001 Lisbon, Portugal
  3. De Almeida, T.M., Instituto Superior Técnico, Technical University of Lisbon, 1049-001 Lisbon, Portugal
  4. Sousa, L.A., Instituto Superior Técnico, Technical University of Lisbon, 1049-001 Lisbon, Portugal
  5. Piedade, M.S., Instituto de Engenharia de Sistemas e Computadores- Investigação e Desenvolvimento, 1000-02 Lisbon, Portugal
  6. Cardoso, F.A., Instituto de Engenharia de Sistemas e Computadores Microsistemas and Nanotecnologias (INESC-MN), 1000-029 Lisbon, Portugal
  7. Ferreira, H.A., Instituto de Engenharia de Sistemas e Computadores Microsistemas and Nanotecnologias (INESC-MN), 1000-029 Lisbon, Portugal
  8. Freitas, P.P., Instituto Superior Técnico, Technical University of Lisbon, 1049-001 Lisbon, Portugal, Instituto de Engenharia de Sistemas e Computadores Microsistemas and Nanotecnologias (INESC-MN), 1000-029 Lisbon, Portugal
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